【摘要】 目的 :探讨莫昔沙星对茶碱药动学的影响 ,为临床合理用药提供参考。方法 :采用自身对照法 ,给家兔静脉注射茶碱 10mg·kg 1 后测定血浆中茶碱浓度 ,停药 7d后 ,灌胃给予莫昔沙星 2 0mg·kg 1 ,qd ,连续 6d ,再静脉注射茶碱10mg·kg 1 后测定血浆中茶碱浓度 ,计算药动学参数。结果 :合用莫昔沙星前后茶碱呈一室模型 ,K值分别为 ( 0 .162±0 .0 5 7) ,( 0 .15 8± 0 .0 5 9)h 1 ;t1 2 分别为 ( 4 .79± 1.85 ) ,( 5 .16± 2 .2 6)h ;V分别为 ( 0 .5 2 4± 0 .10 9) ,( 0 .5 16± 0 .114 )L·kg 1 ;AUC0～ 1 0 分别为 ( 97.3 9± 12 .40 ) ,( 10 1.2 7± 16.49)mg·h 1 ·L 1 ;CL分别为 ( 0 .0 81± 0 .0 18) ,( 0 .0 77± 0 .0 2 1)L·kg 1 ·h 1 ;Cmax分别为 ( 2 0 .0 9± 3 .77) ,( 2 0 .5 3± 4.2 1)mg·L 1 ,合用莫昔沙星前后茶碱的药动学参数差异无显著性 (P >0 .0 5 )。结论 :莫昔沙星对茶碱的血药浓度及药动学参数没有明显影响。更多还原

【Abstract】 Objective:To investigate the effect on the pha rmacokinetic parameters of theophylline by moxifloxacin. Methods:In self-control design with rabbits, the plasma concentrations of theophylline were determined after intravenous dose 10 mg·kg -1 of theophylline alone. Seven days later, moxifloxacin was administrate d orally 20 mg·kg -1 once daily for 6 d. Then determine the plasma concen trations of theophylline after intravenous dose 10 mg·kg -1 of theophylli ne again. The pharmacokinetic parameters of theophylline were calculated. Results:The pharmacokinetics of theophylline used alone and coadministered with moxifloxacin were fit to one compartment model. The phar macokinetic parameters of theophylline used alone and coadministered with moxifl oxacin are as following, K:(0.162±0.057),(0.158±0.059) h -1 ;t 1/2 :(4.79±1.85),(5.16±2.26) h;V:(0.524±0.109),(0.516±0.114) L ·kg -1 ;AUC 0～10 :(97.39±12.40),(101.27±16.49) mg·h·L -1 ;CL:(0.081±0.018),(0.077±0.021) L·kg -1 ·h -1 ;C max : (20.09±3.77) ,(20.53±4.21) mg·L -1 。There were no statis tical significance between pharmacokinetic parameters of theophylline used alone and coadministered with moxifloxacin(P>0.05). Conclusion:Moxifloxacin has little influence on the plas ma concentration and pharmacokinetic parameters of theophylline.更多还原