【摘要】 目的 :探讨β 环糊精 (β CD)包合对乙酰氨基酚 (AAP)的最佳包合工艺。 方法 :运用正交法实验设计 ,对 β CD包合AAP的 3个主要因素 :包合比例、搅拌时间和包合温度进行极差分析和方差分析 ,优选出工艺包合最佳条件。结果 :极差数据为RA>RB>RC ;A因素K3 >K2 >K1 ;B因素K1 >K2 >K3 ;C因素K3 >K1 >K2 。AAP与 β CD比例对包合含量影响显著 (P <0 .0 5 ) ,搅拌时间与温度的水平变化对包合含量差异无显著性 (P >0 .0 5 )。结论 :工艺包合最佳条件为AAP∶β CD比例 =1∶3 ,搅拌时间 6h ,包合温度 40℃。更多还原

【Abstract】 Objective:To probe into the best technology for the inclusion of P acetaminophen(AAP) with beta cyclodextrin(β CD). Methods:The 3 major factors influencing the inclusion ofAAP with β CD, namely inclusion ratio, time of stirring and inclusion temperature were subjected to analysis of variance and range analysis with the use of an orthogonal test in order to optimize the best condition for inclusion technology. Results:Data of the range analysis were R A> R B> R C; factor A: K 3> K 2> K 1; factor B: K 1> K 2> K 3; factor C: K 3> K 1> K 2. The ratio of AAP to β CD was shown to exert a striking effect on the inclusion content( P < 0.05) . Changes in time of stirring and temperature showed little influence on the inclusion content( P > 0.05) . Conclusion:The best conditions for the inclusion technology were shown to be: the ratio of AAP to β CD, 1∶3; the time of stirring, 6 h and the inclusion temperature, 40℃.更多还原