【摘要】 目的 研究右旋泮托拉唑在健康人体内的构型转化。方法 志愿者单剂量口服右旋泮托拉唑肠溶胶囊后,采集血浆样品,用HPLC法测定血浆中泮托拉唑两对映体总浓度,再用α₁-酸糖蛋白手性柱分离泮托拉唑对映体,测定其色谱峰面积比值,计算得到右旋和左旋泮托拉唑血浆浓度,结果 左旋泮托拉唑的平均AUC_0-t不超过泮托拉唑AUC_0-t的1.5％。结论 中国健康志愿者口服右旋泮托拉唑后,在体内不发生构型转化。更多还原

【Abstract】 Aim To study the chiral inversion of dextropantoprazole in human. Methods Three healthyChinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed andused to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasmasamples were measured on a Chirat-AGP column. The plasma concentration of each enantiomer was thencalculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured.Results The AUC_o-1 of levopantoprazole was only 1.5% of the total AUC_0-1 of enantiomers. Conclusion Thechiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese malevolunteers after an oral dose of 40 mg dextropantoprazol.更多还原