【摘要】 目的　阐述药物在经角质层渗透过程中的非平衡态特性 ,为经皮给药技术提供理论和方法。方法　把离体扩散池系统设定为孤立系统 ,建立系统达到平衡态的条件和网络热力学模型。以替硝唑为模式药物 ,进行非平衡态实验和漏糟实验。结果　非平衡态包括 :达到平衡态的长时程性 ;渗透启动的延迟性 ;初始通量的不确定性。漏糟包括 :渗透通量递减性 ;渗透时间常数的可变性。结论　扩散池药物经角质层渗透系统是一个非线性时变系统更多还原

【Abstract】 AimTo illustrate the non-equilibrium properties of drug permeation through stratum corneum (SC) to provide theory and method for transdermal drug delivery. MethodsThe system of side-by-side permeation chambers in vitro was isolated, thus conditions for equilibrium state were decided. And a network thermodynamic model was established. Non-equilibrium and leakage experiments were completed with which tinidazole was pattern drug. ResultsThe properties of non-equilibrium including: long term to reach equilibrium state; delay-start of the permeation; uncertainty of initial drug permeable flux. The properties of leakage including: degression of drug permeable flux; changeability of permeation time constant. Conclusion The permeation cell is believed to be a non-linear and time variable system.更多还原