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Effects of Lanthanum on Formation and Bone-Resorbing Activity of Osteoclast-Like Cells

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【Author】 Zhang Jinchao, Zhang Tianlan)~(1*), Xu Shanjin锦)~1,Wang Kui)~1, Yu Shifeng)~3, Yang Mengsu)~4(1. Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China; 2. Department of Chemistry, College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China; 3. Department of Oral Pathology, Stomatological Hospital, Peking University, Beijing 100081, China;(4. Department of Biology and Chemistry, City University of Hong Kong, Hon)g Kong)

【机构】 Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University,Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University,Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University,Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University,Department of Oral Pathology, Stomatological Hospital, Peking University, Beijing 100081, China,Department of Biology and Chemistry, City University of Hong Kong, Hon)g Kong Beijing 100083, China； Department of Chemistry, College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China, Beijing 100083, China, Beijing 100083, China, Beijing 100083, China；

【Abstract】 The effect of La³⁺ on formation of osteoclast-like cells in rabbit bone marrow cells induced by 1,25-dihydroxyvitamin D₃ and their bone-resorbing activity was evaluated by counting the number of tartrate resistant-acid phosphatase-positive [TRAP（+）] multi-nucleated cells and measuring the number and surface area of bone resorption pits with photomicrography and image analysis. The formation and morphological characteristics of osteoclast-like cells and bone resorption pits were observed under a phase contrast inverted microscope. La³⁺ promotes the formation of osteoclast-like cells at the concentration of 1.00×10^-8mol·L^-1 compared with the control group（P<（0.01））, whereas no significant change in cell number is observed at higher concentrations(1.00×10^-5, （1.00×）10^-6 and 1.00×10^-7 mol·L^-1)（P>0.05）. La³⁺ at the concentration of 1.00×10^-8mol·L^-1 also increases the number and surface area of the resorption pits（P<0.01）, but inhibits the bone-resorbing activity dose-dependently（P<0.01）at higher concentrations(1.00×10^-5, 1.00×10^-6 and 1.00×10^-7 mol·L^-1). These findings suggest that La³⁺ may promote or inhibit the formation and bone-resorbing activity of osteoclast-like cells depending on its concentration.更多还原

【关键词】 lanthanum； osteoclast-like cells； 1, 25-dihydroxyvitamin D₃； bone marrow cells； bone resorption； rare earths；
【Key words】 lanthanum； osteoclast-like cells； 1, 25-dihydroxyvitamin D₃； bone marrow cells； bone resorption； rare earths；

【基金】 ProjectsupportedbyNationalNaturalSciencesFoundationofChina(2 0 0 3 10 10 ;2 0 2 710 0 5 )

【文献出处】 Journal of Rare Earths ,稀土学报(英文版) , 编辑部邮箱 ,2004年06期

【分类号】Q813
【被引频次】11
【下载频次】61

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