【摘要】 目的:建立测定阿德福韦酯原料药含量的非水酸碱电位滴定方法。方法:以无水冰醋酸-醋酐(1:3)作为溶剂,以高氯酸标准溶液(0.1 mol/L)为滴定剂进行非水电位滴定。结果:阿德福韦酯原料药平均含量为99.7％,RSD为0.2％。结论:本方法准确,重现性好,适用于阿德福韦酯原料药的质量控制。更多还原

【Abstract】 Objective: To establish nonaqueous acicle - base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods:75% acetric anhydride was selected as the solvent, and 0. 1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results:It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99. 7% and RSD was 0. 2% . Conclusion:The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.更多还原