【摘要】 目的 :研究褪黑素对吗啡依赖大鼠复吸行为的抑制作用。方法 :以剂量递增法连续皮下注射 (sc)吗啡 6d建立吗啡诱导的大鼠条件性位置偏爱 (CPP)模型 ,d7用生理盐水替代吗啡训练大鼠 10d ,以使形成的CPP逐渐消退。单次sc 4mg·kg- 1 吗啡以唤起消退的CPP的恢复。部分大鼠在注射吗啡前 30min分别腹腔注射 (ip)褪黑素 2 0、4 0和 80mg·kg- 1 进行治疗。结果 :与吗啡依赖组相比 ,在sc 4mg·kg- 1 吗啡引燃刺激前 30min应用褪黑素 4 0和 80mg·kg- 1 急性治疗 ,可以使大鼠在伴药箱的停留时间明显缩短 ,(P <0 0 5、P <0 0 1) ;而褪黑素 2 0mg·kg- 1 急性治疗亦使大鼠在伴药箱的停留时间缩短 ,但无统计学意义 ,P >0 0 5。结论 :褪黑素在一定程度上可以抑制吗啡引燃的吗啡依赖大鼠的复吸行为更多还原

【Abstract】 Objective: To study the inhibitory efficacy of melatonin (Mel) on relapse behavior in morphine-dependent rats. Methods: Morphine was administered via subcutaneous injection at gradually increasing doses (from 10 mg·kg -1 to 60 mg·kg -1 ) for 6 days to establish morphine conditioned place preference(CPP). From Day 7, the rats were administered saline instead of morphine for 10 days to induce CPP extinction. The rats then were given a single priming injection of morphine 4 mg·kg -1 to reinstate the morphine CPP. Some rats were treated by ip melatonin (20, 40 and 80 mg·kg -1 ) prior to priming injection of morphine. Results: After priming injection of morphine 4 mg·kg -1 , the time spent on the drug-paired side was significantly reduced because of the treatment with Mel(40 and 80 mg·kg -1 ), compared with Mor Group P<0 05, P<0 01. No significant statistical differences were observed between Mor Group and Mel 20 Group (P> 0 05). Conclusion: Mel has some effects on the inhibitory of relapse behavior induced by priming injection of morphine in morphine-dependent rats.更多还原