【摘要】 目的　观察不稳定心绞痛患者血管性假血友病因子 (vWF)及同型半胱氨酸 (Hcy)水平的变化。方法　不稳定心绞痛患者 4 4例及冠状动脉造影正常患者 17例在入院次晨空腹采血 ,而健康体检人群 2 0例在当日空腹采血 ,测定vWF及Hcy水平。结果　不稳定心绞痛患者vWF及Hcy水平 [vWF(194 .36± 32 .2 3) % ,Hcy(12 .89± 5 .18) μmol L]较冠状动脉造影正常患者 [vWF(16 9.0 0± 2 0 .6 9) % ,Hcy(7.4 0± 5 .18) μmol L]和健康体检人群 [vWF(15 3.0 0±2 4 .73) % ,Hcy(4 .98± 1.5 9) μmol L]均明显升高。 结论　vWF及Hcy水平的改变可能参与了不稳定心绞痛的病理生理过程更多还原

【Abstract】 Objective To observe the levels of von Willebrand factor(vWF) and homocysteine(Hcy) in patients with unstable angina pectoris(UAP).Methods Plasma levels of vWF and serum levels of homocysteine were measured by ELISA from 44 patients with UAP, 17 patients whose results of CAG were normal, and 20 healthy individuals.Results The levels of circulating vWF and Hcy in UAP [vWF(194.36±32.23)%, Hcy(12.89±5.18) μmol/L]were significantly higher than which in the individuals whose results of CAG were normal [vWF(169.00± 20.69)%, Hcy(7.40 ±5.18) μmol/L]and the healthy individuals. Conclusion Plasma vWF and Hcy may be possibly involved in the pathophysiology of UAP [vWF(153.00±24.73)%, Hcy(4.98±1.59) μmol/L].更多还原