【摘要】 目前,脑水肿和脑梗塞的病人主要是通过CT等方法进行检查的,虽可准确判断瞬时脑水肿的范围和程度,但由于它们不适合用于临床监护,为病情的检查带来不便。科学研究表明,脑电阻抗的变化与脑水肿、脑梗塞有极大的关系,脑电阻抗是脑水肿灵敏的检测指标,该文研究了将电脑阻抗方法应用于脑水肿监护的原理和测量装置。研究小组进行了双道头颅电阻抗的理论和临床研究,在动物和人体头皮上以接触方式实现了颅内电阻抗的测量方法,验证脑电阻抗与脑水肿的关系。在此基础上首次提出了电脑阻抗地形图的概念,应用自行设计的脑电阻抗地形图检测系统,对临床脑水肿患者进行了初步检测。结果发现,该系统可比较敏感地反映脑梗死后的缺血性水肿,且阻抗地形图显示阻抗值升高的范围与CT显示的水肿范围基本一致,提示通过脑电阻抗地形图检测,能反映脑缺血后缺血区组织水肿的严重程度,同时还能反映水肿的部位及范围。该方法的进一步研究有可能为脑水肿检测提供一种无创、床旁使用、能连续监护的方法和设备。更多还原

【Abstract】 Nowadays the normal measurement ways of brain edema are CT MRI etc. They can present the results of instantaneous range and degree of the brain edema exactly but it is difficult to utilize them for clinical monitoring. Study reveals the great relationship between the change of brain electrical impedance and edema. The brain electrical impedance is a sensitive parameter of brain edema. In this article the principle of brain edema monitoring based on brain-electrical-impedance method and the measurement are introduced. A two-paths coronal electrical impedance method and its clinical study are performed. The endocranial electrical impedance measurement is realized with contact method namely putting the electrode on the head of the animal or person. The results validate the relationship between brain-electrical-impedance and edema. Then the concept of Brain Electrical Impedance Topographic Mapping BEITM is given and some brain edema patients are examined with the measuring system designed by us. The system can sensitively image the edema aroused by the shortness of blood after brain infarct and the range of impedance rising in BEITM is consistent with the result of CT. So the messages of the edema including the location and condition can be got with BEITM. With the progress of the research a non-invasive continuous monitoring method and equipment at the bedside for brain edema measurement may be developed.更多还原