DIFFERENTIAL DIAGNOSIS IN THE INTRACRANIAL DISEASES: PROTON MAGNETIC RESONANCE S PECTROSCOPY STUDY

【Abstract】 Objective To investigate th e value of proton magnetic resonance spectroscopy ( 1H-MRS) on diagnosis a nd differential diagnosis of the intracranial diseases by the MRS results of 52 patients. Methods 12 patients with benign glioma, 16 patients with malignant glioma, 10 patients with meningioma, 8 patients with virus encephalitis, and 6 patients with cerebral infarction underwent MRS in th e lesion region. We measured the area within the spectra of N-acetyl-aspartate (NAA), creatine/phosphocreatine (Cr), choline compounds (Cho), and lactate (Lac ). Results The spectra of meningiomas were characterized by abs ence of NAA. The spectra of gliomas were characterized by the decrease of NAA an d Cr, but the increase of Cho. The ratio of Cho to Cr was 2.25±1.21 in benign g liomas, while the ratio of Cho to Cr was 4.65±2.21 in malignant gliomas. The sp ectra of virus encephalitis appeared the decrease of NAA and the normality of Cr , with the 1.25±0.21 ratio of Cho/Cr. The apparent Lac wave could be seen in al l cerebral infarctions. Conclusion The value of 1H-MRS plays a significant role in the diagnosis and differential diagnosis of gliomas, mening iomas, virus encephalitis, and cerebral infarctions.更多还原