【摘要】 目的　建立合适大鼠糖尿病动物模型。方法　选取健康大鼠 2 2只 ,体重为 180～ 2 40 g ,随机分为实验组 1、实验组 2、实验组 3、正常组。实验 1～ 3组腹腔注射四氧嘧啶 ,注射剂量分别为 15 0mg/kg、175mg/kg、2 0 0mg/kg(按体重计算 ) ,经 48h后取血清测定其血糖的变化。结果　实验 1～ 3组大鼠血糖均显著高于正常对照组 (P <0 .0 1) ;实验 3组的血糖显著高于实验 2组和实验 1组 (P <0 .0 1) ;实验 2组显著高于实验 1组 (P <0 .0 1)。结论　大鼠腹腔注射四氧嘧啶建立糖尿病模型是一种可靠、易控制的方法。血糖的升高与体重、鼠龄有关。更多还原

【Abstract】 Objective To establish suitable diabetic rats models. Methods Twenty-two healthy rats, weighed 180～240g, were randomly allocated to experimental groups 1～3, and a control group. The experimental groups 1～3 were intraperitoneally injected with alloxan 150mg/kg, 175mg/kg and 200mg/kg, respectively. The blood sugar was detected 48 hours after the injection. Results In laboratory groups 1～3, the blood sugar levels were significantly higher than that in the control group (P<0.01); the blood sugar in group 3 was higher than those in groups 2 and 1 (P<0.01); group 2 higher than group 1 (P<0.01). Conclusion The establishment of diabetic rats models by intraperitoneal injection with alloxan is an easy and simple method. The elevation of blood sugar might be correlated with the rats weight and ages.更多还原