【摘要】 目的　仿真前、后负荷改变及各种瓣膜病情况下 ,左心室压力 容积关系的改变。方法　应用Ursino所建立的全循环系统集中参数模型 ,对跨瓣流动方程作了适当修改。结果　首先 ,讨论了心室前负荷、后负荷和心肌收缩力对左心室压力 容积关系的影响 ;在此基础上仿真了二尖瓣狭窄、二尖瓣关闭不全 ,主动脉瓣狭窄和主动脉瓣双病变的左心室压力 容积环。结论　仿真结果显示了心脏瓣膜疾病对左心室功能的影响 ,同时说明集中参数模型不但能描述血管系统 ,也能较好地模拟心脏功能更多还原

【Abstract】 Objective The purpose of this paper is to simulate the alterations of pressure-volume loop of left ventricle due to the changes of pre- and after-load and induced by cardiac valve diseases. Methods The simulations were performed by using Ursino model, which took into account the whole circulation system including heart, arterial and venous systems. The equations of flow across heart valves were modified in order to calculate the reverse flow in the condition of valves diseases. Results Firsly, the influences of pre-load, after-load of left ventricle and myocardial inotropism on ventricular pressure-volume loops were calculated. Based on these data, the pressure-volume loops with mitral obstruction, mitral inadequacy, aortic stenosis and both aortic stenosis and insufficiency were simulated. Conclusion The results showed that there are significant influences of heart valves disease on the left ventricle function. It also indicated that the clamped parameter model describing the whole cardiovascular system is an adequate tool to be applied to simulate not only vascular system, but also the heart function.更多还原