【摘要】 目的　观察ATZ 2 16对大鼠心肌缺血再灌注损伤(MI/RI)的作用。方法　结扎冠状动脉左前降支 30min、再灌注 12 0min制备大鼠MI/RI模型。采用心电图、心肌酶及病理学方法观察心肌的损伤程度。结果　ATZ 2 16 16 0mg/kg能降低大鼠MI/RI时心电图ST的抬高 ,4 0、80、16 0mg/kg均能减少心肌酶的释放、减轻心肌梗死范围并呈一定的量效关系。结论　ATZ 2 16对大鼠MI/RI有一定的保护作用。更多还原

【Abstract】 Objective To investigate whether ATZ-216 has protective effect on myocardial ischemia-reperfution injury(MI/RI) in rats. Methods MI/RI models were established by the left anterior descending coronary occlusion 30 min and reperfusion 120 min in rats. The degree of myocardial injury was investigated with electrocardiograph, myocardial enzyme in serum and histopathology examination. Results ATZ-216 160 mg/kg significantly decreased the level of ST segment. ATZ-216 at 40, 80, 160 mg/kg all decreased the level of myocardial enzyme in serum and significantly and dose-dependently decreased the size of myocardial infarction. Conclusion ATZ-216 has protective effects on MI/RI.更多还原