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促性腺素释放素类似物联合体外受精治疗子宫内膜异位症不孕症

Pregnancy results of infertility in endometriosis with gonadorelin release hormone analogue and in vitro fetilization

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【作者】 杨帆施祖美金炜邵敬於凌梅立

【Author】 YANG Fan 1, SHI Zu mei 1, JIN Wei 2, SHAO Jing yu 2, LING Mei li 2 (1. Reproductive Medicine Center, Huashan Hospital Affiliated To Fudan University, SHANGHAI 200040, China; 2. Shanghai First Merternity and Infant Health Hospital, SHANGHAI 200040, China)

【机构】 复旦大学附属华山医院生殖医学中心上海市第一妇婴保健院上海市第一妇婴保健院 上海200040上海200040上海200040

【摘要】 目的 :探讨不孕症合并子宫内膜异位症病人应用促性腺素释放素类似物 (GnRH A)联合体外受精 (IVF)的妊娠效果。方法 :5例子宫内膜异位症 ,其中 3例为子宫肌腺病。先使用GnRH A治疗3~ 6mo ,待月经来潮后采用促性腺激素超排卵治疗 ,卵泡成熟后采卵 ,常规体外受精 胚胎移植 (IVF ET)。结果 :发现排卵期血催乳素 (PRL)增高 ,治疗后 5例妊娠 ,住院保胎 ,3例足月妊娠分娩 ,2例流产。结论 :子宫内膜异位症合并不孕症应用GnRH A治疗 3~ 6mo后IVF效果较好。

【Abstract】 AIM: To explore pregnancy results of infertility in endometriosis with gonadorelin release hormone analogue (GnRH A) in combination with in vitro fertilization (IVF). METHODS: In 5 patients, 3 patients suffered from adenomyosis. They were treated with GnRH A for 3 6 mo at first, once the patients’s menstruation was coming and they were used controlled ovarian hyperstimulation (COH). When their follicles grow up to maturation, they were picked up and done IVF and embryo transfer. RESULTS: During ovulation, their PRL in blood insereased. All of patients got pregnancy and stayed in hospital for keeping embryos. Among them, 3 patients naturally labored and 2 patients aborted. CONCLUSION: IVF will be more effective after 3 6 mo treatment of infertility in endometriosis with GnRH A.

  • 【文献出处】 中国新药与临床杂志 ,Chinese Journal of New Drugs and Clinical Remedies , 编辑部邮箱 ,2004年04期
  • 【分类号】R711.6
  • 【被引频次】6
  • 【下载频次】118
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