【摘要】 目的 :观察多塞平加氟桂利嗪治疗难治性功能性消化不良 (FD)的疗效。方法 :应用随机开放性的自身交叉对照试验 ,6 3例病人分为AB组和BA组 ,轮替给予A方案和B方案先后治疗各 4wk。A方案给多塞平 12 .5mg ,po ,bid +2 5mg ,po ,qn ;氟桂利嗪 5mg ,po ,qn。B方案给西沙必利 5mg ,po ,tid ;雷尼替丁 0 .3g ,po ,qn。A和B方案间隔 3wk执行 ,2组病人在A和B方案均完成后 ,相同方案的症状评分结果合并 ,再比较症状改善情况及有效率。结果 :治疗后 2方案的症状积分下降均有非常显著意义 (P <0 .0 1) ;2方案间比较 ,A方案症状积分非常显著低于B方案 (P <0 .0 1) ,症状总积分减分率达有效者 ,A方案 75 % ,非常显著高于B方案 4 4% (P <0 .0 1)。结论 :多塞平加氟桂利嗪是治疗难治性FD的有效方案。更多还原

【Abstract】 AIM: To observe the therapy effect of doxepin combined with flunarizine in treating intractable functional dyspepsia(FD). METHODS: Using self control random cross over test, 63 patients were divided into two groups (AB and BA group) and were treated for 4 wk with design A and for 4 wk with design B. Design A took doxepin 12.5 mg po, bid +25 mg po, qn, and flunarizine 5 mg po, qn. Design B took cisapride 5 mg po, tid, and ranitidine 0.3 g, po, qn. There were 3 wk interval between two designs. Two designs were executed in reverse order in two groups each other. By the end of the two designs, the symptom scores of the same designs in two groups were compared, and then the symptom scores between two designs were compared. RESULTS: After treatemnt, symptom scores were significant lower than those before in two designs (P<0.01); but they were significant lower in design A than those in design B (P<0.01) and the effective rate was significant higher in design A 75 % than that in design B 44 %(P<0.01). CONCLUSION: Doxepin combined with flunarizine is a more effect treatment program for intractable FD.更多还原