【摘要】 目的 :探讨子宫内膜异位症 (内异症 )病灶的血管特点与形成机制。方法 :采用LSM5 10激光共聚焦显微镜对 5 3例卵巢和骶韧带内异症病灶 (内异症病灶组 )进行观察 ,并取同期 2 0例子宫腺肌病在位内膜 (子宫腺肌病组 )与 2 1例子宫肌瘤在位正常内膜 (正常对照组 )进行对比分析。结果 :内异症病灶组内无论增殖期还是分泌期均以幼稚型血管为主 ;内异症病灶组中Ⅲ、Ⅳ期的子宫内膜血管内皮面积 [(376± 10 2 ) μm2 ]明显高于Ⅰ、Ⅱ期 [(132± 5 5 ) μm2 ](P <0 0 5 )。内异症病灶组的分泌期内膜血管内皮面积、周径与直径与增殖期相比具有缩小趋势 ,导致其容易脱落与种植。结论 :内异症病灶的血管随着病情的进展仅血管面积有所增大 ,但病灶内血管类型并未改变 ,以幼稚血管为主。子宫内膜异位症病灶的血管形成改变可能与其内膜的异位种植有关。更多还原

【Abstract】 Objective:To investig ate the characteristics of angiogenesis in endometriosis.Methods:Confocal microscopy LSM510 was used to analyze 53 cases of ovarian endometriosis and endometriosis on sacrum ligament.20 cases ectopic endometrium of adenomyosis and 21 cases normal endometrium of leiomyoma served as the controls.Results:Comparing with the controls,the type of blood vessels of endometriosis lesion were immature in spite of the stage of endometrium,P<0.05.Th e area of stage Ⅲ,Ⅳ[(376±102)μm2] was significant higher than that of stage Ⅰ,Ⅱ[(132±55)μm2],P<0.05.However,the primet er and diameter were not different.Area,perimeter and diameter of endometriosis lesion in secretory stage were all smaller than proliferation stage.And this might cause the endometrium falling off and then implanting.Conclusion:Vascula r change exists in endometriosis lesion.It may play a role in the ectopic implantation of endometrium. [更多还原