【摘要】 目的:考察6厂家替硝唑片剂的溶出度。方法:按照中国药典2000年版附录中溶出度项下第一法,以紫外分光光度法测定含量,转篮法测定溶出度,并对其溶出参数进行统计处理。结果:6厂家替硝唑片的溶出速率相差很大(P<0.01)。结论:建议加强对药品溶出度的监测,确保药品质量。更多还原

【Abstract】 Objective:To investigate the dissolubilities of tinidazole tablets produced by different factories and compare them. Methods:According to Chinese pharmacopoeia (2000) dissolubility method Ⅰ.The contents of tinidazole tablets were determined by UV spectrophotometry, the dissolubilities were determined by basket-converted method and the dissolution parameters(Td、T50、m) were processed statistically.Results:There were significant differences in dissolubility among the products from 6 factories(P<0.01).Conclusion:It is suggested that monitoring of drug’ dissolution should be enhanced to control drug’ quality.更多还原