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89Sr治疗骨质疏松性骨折的临床研究

Clinical study of strontium-89 for treating osteoporotic fracture

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【作者】 吴建能张巧云潘灶银林拓郭湘云窦文华

【Author】 WU Jian_neng,ZHANG Qiao_yun,PAN Zao_yin,et al.(Department of Endocrinology,The People’s Hospital of Yubei,Guangdong 512026,China)

【机构】 粤北人民医院韶关医学院生理教研室粤北人民医院 广东韶关512026广东韶关512026广东韶关51202广东韶关512026

【摘要】 目的 :探讨89Sr(锶 )治疗骨质疏松性骨折及其引起顽固性疼痛的疗效。方法 :对12例骨质疏松性骨折患者静脉注射89Sr,比较治疗前后患者疼痛程度及骨质量 (BMD)的改变 ,并与对照组比较。结果 :静脉注射 89Sr5~10天后 ,11例疼痛完全缓解(Ⅰ级) ,1例明显好转、仅轻度疼痛(Ⅱ级) ,总有效率100 %。治疗前后腰椎BMD百分率变化:显效4例 ,有效5例 ,无效3例 ,总有效率75 %。与对照组比较效果明显(P<0.05)。结论 :静脉注射 89Sr能有效治疗骨质疏松性骨折及其引起的顽固性疼痛。

【Abstract】 Objective:To explore the curative effect of strontium-89(89Sr)for treating osteoporotic fracture and refractory soreness caused by this disease.Methods:12 patients with osteoporotic fracture were given 89Sr by intravenous injection.The degree of pain and change of BMD were compared before and after treatment,and also compared with those in the control group.Results:In 5~10 days after 89Sr injection,the soreness relieved completely in 11 cases(grade Ⅰ),the patient was obvious on the mend in 1 case,with a little pain(grade Ⅱ).The total effective rate was 100%.The percentage of BMD was changed before and after treatment:4 cases were notable curetive effect,5 cases were effective,3 cases were ineffective,The total effective rate was 75%.Conclusion:89Sr intravenous injection can effectively treat the osteoporotic fracture and refractory soreness caused by this disease.

【关键词】 89Sr骨质疏松骨折
【Key words】 StrontiumOsteporosisFracture
【基金】 本课题为广东韶关市科研基金资助项目【韶科(卫)2004-9】
  • 【文献出处】 现代医药卫生 ,Modern Medicine Health , 编辑部邮箱 ,2004年23期
  • 【分类号】R817.4
  • 【被引频次】2
  • 【下载频次】64
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