【摘要】 目的　探讨无创正压通气在慢性阻塞性肺疾病 (COPD)急性加重致中轻度呼吸衰竭中的疗效。方法　　符合COPD住院患者分为 3组 :A组 10例 ,PaO2 <5 5mmHg且 6 0mmHg >PaCO2 >4 5mmHg ;B组 12例 ,PaO2 <5 5mmHg且PaCO2 >6 0mmHg ;C组 16例 ,PaO2 <5 5mmHg且PaCO2 >4 5mmHg ,拒绝无创通气治疗。A、B组给予无创正压通气 +常规治疗。C组仅常规治疗。治疗前后监测血气分析及临床症状变化。结果　无创正压通气组 1h后血气指标及一般情况明显改善 ,2 4h继续改善 ,常规治疗组 1h上述指标无改善 ,2 4h时比治疗前有所改善 ,但改善较无创正压通气组有显著差异。结论　无创正压通气是COPD呼吸衰竭的一线治疗方法。更多还原

【Abstract】 Objective To explore the regiment of noninvasive intermittent positive pressure ventilatian (NIPPV) in treatment of mild to moderate respiratory failure due to acute exacerbation of COPD.Method The patients were divided into three groups, group A:10 patients with PaO 2<55mmHg and 60mmHg> PaCO 2>45mmHg;group B:12 patients with PaO 2<55mmHg and PaCO 2>60mmHg;group C:16 patients who refused mechanical ventilation with PaO 2<55mmHg,PaCO 2>45mmHg,group A and B—NIPPV plus conventional therapy;group C—conventional therapy only.Results The value of blood gas analysis and clinical signs of group A,B were significantly improved after 1 hour of NIPPV and continually improved within 24 hours.The parameters above did not improve with group C,but after 24 hours treatment, the parameters of blood gas analysis and clinical signs improve significantly.But there was significant difference with that of group A, B.Conclusion Noninvasive positive pressure ventilation is the first line of effective treatment of COPD with respiratory failure.更多还原