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逐瘀胶囊制备工艺的研究

Study on Technique of Preparating Zhuyu Capsule

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【作者】 王爱武吴丽敏耿晖田景奎祝侠丽

【Author】 WANG Ai-wu, WU Li-min, GENG Hui, et al (Shangdong Provincial Hospital, Jinan 250021, China)

【机构】 山东省立医院山东大学药学院 山东济南250021山东济南250021山东济南250002

【摘要】 目的 研究逐瘀胶囊的制备工艺。方法 以L9(34)正交设计,采用水提醇沉法,优选水蒸气蒸馏提取挥发油及挥发油β-CD包合的最佳工艺。结果 挥发油的最佳提取工艺为:加水10倍、7倍,提取2次,分别为4、3 h。最佳包合工艺为:挥发油与β-CD的比例为1∶10,包合温度40 ℃,包合时间1.5 h。水提静沉工艺优于水提醇沉工艺。结论 逐瘀胶囊的制备工艺符合现代制剂的有关要求。

【Abstract】 Objective To study on preparation of Zhuyu Capsule. Methods The best techniques for essential oil extracted by steam distillation andβ-CD inclusion were obtained by L9(34) orthogonal test. The refined method was studied by water-ethanol extracting. Result The best technique for essential oil extracted by steam distillation was two times, ten and seven times water,4 h and 3 h each time.The bestinclusion was essential oil∶β-CD 1∶10, 40℃ and 1.5 h. The refined technique of cool precipitation was finer than ethanol precipitation. Conclusion The technique of Zhuyu Capsule was up to the standard of modern preparation.

【关键词】 逐瘀胶囊β-CD包合制备工艺
【Key words】 Zhuyu Capsuleβ-CD inclusiontechnique procedure
  • 【文献出处】 中国中医药信息杂志 ,Chinese Journal of Information on TCM , 编辑部邮箱 ,2004年10期
  • 【分类号】TQ461
  • 【下载频次】77
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