【摘要】 目的对比研究静脉注射胺碘酮与普罗帕酮转复阵发性心房颤动(房颤)的作用。方法72例房颤持续时间<48h的患者随机分为二组,胺碘酮组(n=36):胺碘酮150mg+生理盐水10ml,静注,10min注完;普罗帕酮组(n=36):普罗帕酮70mg+生理盐水10ml,静注,5～10min注完。观察30min若未转复可重复应用,最大累积量胺碘酮为450mg,普罗帕酮为210mg。结果转复率:胺碘酮组77.8％(28/36),普罗帕酮组75.0％(27/36),二组转复率比较差异无统计学意义(x2=0.0770,P>0.05)。转复时间:胺碘酮组(50.1±14.8)min,普罗帕酮组(39.6±13.7)min,二组比较差异有统计学意义(t=3.124,P<0.01)。结论胺碘酮和普罗帕酮对阵发性房颤均有较高的转复率,但转复时间普罗帕酮短于胺碘酮。更多还原

【Abstract】 Objective To compare efficacies of intravenous amiodarone and propafenone in converting paroxysmal atrial fibrillation (AF). Methods 72 patients with atrial fibrillation lasting < 48 hours were randomly divided into two groups: Group 1 ( n - 36), treated intravenously with 150mg amiodarone and 10ml normal saline within 10 min; Group 2(n =36), treated intravenously with 70mg propafenone and 10ml normal saline within 5-10min. After 30 minutes, if the resuscitation was not good,the above intravenous injection can be given again, the maximum accumulated dose was 450mg (amiodarone) and 210mg(propafenon). Results The resuscitation rate of two groups was 77. 8% (28/36) and 75.0%(27/36),respectively(x2 = 0.0770,P>0. 05).The resuscitation duration for the two groups was (50.1 ± 14.8)min and (39.6± 13.7)min respectively, t = 3.124,P<0.01. Conclusion Both amiodarone and propafenone have a high efficacy in treatment of AF.but for the resuscitation duration, propafenone is shorter.更多还原