【摘要】 松果体激素美乐托宁又名褪黑激素 ,除与人体生物节律的形成与调控密切相关外 ,还在心血管系统功能的调节中发挥重要作用。超生理剂量的美乐托宁不仅具有明显的抗脂质过氧化、防治缺血再灌注性心肌损伤和心律失常特性 ,长期服用还可使血压下降 ,并有助于恢复动脉血压的昼夜节律性。其强大的清除自由基功能在多种类型的高脂血症预防和治疗方面具有广泛的应用前景。但美乐托宁对心血管系统疾病的确切作用机制及安全性和有效性 ,尚需要广泛的基础研究和大规模的临床验证。更多还原

【Abstract】 Pineal hormone melatonin plays an important role in regulation of multiple cardiovascular functions as well as in the formation and organization of biorhythms.Over physiological dosage of melatonin not only depress lipid peroxidation,prevent and cure post ischemic-reperfusion cardiac injury and arrhythmias,but reduce the elevated systemic blood pressure and restrain the day-night rhythms by long-term medication.Its potential free radical scavengering property promises an extensive perspective in the management of various hyperlipaemia.The exact mechanisms of melatonin on cardiovascular disease,its safety and efficiency call for extensive basic studies and large scale clinical trials.更多还原