【摘要】 心肌间质胶原网络在维持心肌正常结构和功能完整性方面起着重要的作用 ,胶原过多蓄积将引起心肌纤维化。心肌胶原代谢受多种因素调控 ,这些因素涉及肾素 血管紧张素 醛固酮系统、内皮素、儿茶酚胺、缓激肽、生长因子、一氧化氮、基质金属蛋白酶 金属蛋白酶组织抑制剂及细胞内钙等。更多还原

【Abstract】 The collagen network of myocardial interstitium plays important roles in maintaining the normal instructure of myocardium and integrity of function.The excessive accumulation of collagen will result in myocardial fibrosis.The metabolism of cardiac collagen is regulated by many factors which concern renin-angiotensin-aldosterone system,endothelin,catecholamine,bradykinin ,growth factor,nitric oxide,matrix metalloproteinases-tissue inhibitor of matrix metalloproteinases and intracellular calcium,etc.更多还原