【摘要】 目的　探讨儿童先天性病残与弓形虫感染的关系。方法　应用间接血凝试验 (IHA)和膜抗原酶联免疫吸附试验 (EL ISA)检测 2 97例先天性病残儿童血清弓形虫抗体。结果　 2 97例先天性病残儿童弓形虫抗体阳性率 2 1.2 1% (6 3/ 2 97) ,显著高于后天获得性病残儿童弓形虫抗体阳性率15 .2 5 % (45 / 2 95 ) (χ2 =3.5 2 ,P<0 .0 5 )及同期健康儿童弓形虫抗体阳性率 6 .76 % (10 / 14 8) (χ2 =15 .0 5 ,P<0 .0 1)。先天性病残儿童父、母弓形虫抗体阳性率 (父 2 1.5 5 %、母 2 9.97% )与同期健康儿童父、母弓形虫抗体阳性率 (父 4 .0 5 %、母 5 .4 0 % )相比较 ,差异有显著性 (父 -父 χ2 =2 2 .81、OR=6 .5 0、P<0 .0 1,母 -母 χ2 =34.96 ,OR=7.4 9、P<0 .0 1)。与后天获得性病残儿童父、母弓形虫抗体阳性率 (父 15 .5 9%、母 2 1.6 9% )比较 ,差异均具有显著性 (父 -父 χ2 =3.4 7,P<0 .0 5 ,母 -母 χ2 =5 .2 8,P<0 .0 1)。10 8例弓形虫抗体阳性的儿童病残家庭 ,父或母至少有一方弓形虫抗体呈阳性的家庭有 5 6户 ,占阳性病残儿家庭的 5 1.85 %。提示弓形虫感染与优生优育关系密切。结论　弓形虫感染是儿童先天性病残的重要致残因素之一 ,对优生优育夫妇积极开展弓形虫感染的血清学监测 ,将对提高人口素质 ,更多还原

【Abstract】 Objective To explore the rela ti onship between Toxoplasma gondii infection and c ongenital disability in children. Methods By us ing specific surface membrane antigen ELISA and IHA,297 children with congenital disability and their parents were examined for the anti-Toxopl asma antibodies. Results The antibody positive rate in children with congenital disability was 21.21% (63/297),which was significantly higher t han that in children with acquired disability 15.25% (χ2=3 .52,P<0.05), and that of healthy children 6.76% (χ2=15.05,P<0.01).Conclusion Toxoplasma infection is one of the reasons for congenital disability in children.更多还原