【摘要】 目的　探索反复化疗地区日本血吸虫对吡喹酮的敏感性。方法　从洞庭湖反复化疗区及新流行区现场收集获取感染性钉螺 ,分别逸蚴、分组感染小鼠 ;5周后再分对照组和治疗组 ,治疗组用吡喹酮 (6 0 0 mg/ kg体重 ) 1次灌服 ,治疗后 3周与对照组同时剖杀 ,观察记录各组成虫、肝卵、粪卵数和粪便毛蚴孵化阳性率。结果　反复化疗地区与新流行区吡喹酮治疗组减虫率分别为98.2 4 %、98.71% ;粪卵减少率分别为 99.94 %、99.6 4 % ;肝卵减少率分别为 75 .85 %、73.10 % ;两者差异均无显著性。对照组均有毛蚴孵出 ,而各治疗组鼠粪均无毛蚴孵出。结论　洞庭湖反复化疗地区日本血吸虫对吡喹酮敏感性没有发现降低 ,与新流行区比较差异亦无显著性更多还原

【Abstract】 Objective To explore susceptibility of praziquantel(PQT) against Schistosoma japonicum in the repeated chemotherapy areas in Dongting Lake region of China. Methods Sixty mice were divided into two groups, and infected respectively by cercariae released from the infected snails which were collected from new and old endemic areas. After 5 weeks, the mice in each group were divided into control groups and treatment groups (PQT group). The mice in each PQT group were treated with a single oral dose of praziquantel (600 mg/kg). Three weeks post treatment, mice were dissected, and the number of adults, the stool eggs per gram (EPG), the liver EPG and the hatching rates were observed. Results The worm reduction rates of the PQT groups of new and old epidemic areas were 98.24% and 98.71% respectively, and the stool egg reduction rates 99.94% and 99.64%, the liver egg reduction rates 75.85% and 73.10%,and there were no significant differences between the new and old endemic areas. The stool hatching test was positive in the control groups, and negative in the PQT groups. Conclusion Susceptibility of praziquantel against Schistosoma japonicum does not decrease in repeated chemotherapy areas in Dongting Lake region.更多还原