【摘要】 基于盐酸介质中高锰酸钾直接氧化甲磺酸酚妥拉明产生化学发光这一现象,建立了一种简易、快速测定甲磺酸酚妥拉明的流动注射化学发光新方法.在优化的实验条件下,本法测定甲磺酸酚妥拉明的线性范围为0 05～6μg/mL,检出限为0 01μg/mL,对浓度为4 0μg/mL的甲磺酸酚妥拉明进行11次平行测定,得到相对标准偏差为3 0%.将本法用于针剂及尿样和血样中甲磺酸酚妥拉明的测定,结果令人满意.更多还原

【Abstract】 A fast and simple chemiluminescence(CL) method for the determination of phentolamine mesylate is proposed based on its direct oxidation with potassium permanganate in acidic media. In the optimum conditions, CL intensities are proportional to concentrations of the studied drug over the range 0.05-6 μg/mL with a detection limit of 0.01 μg/mL. The relative standard deviation (RSD) is 3.0% for 4 μg/mL phentolamine mesylate (n=11). The method has been applied to the determination of studied drug in injections and biological fluids with satisfactory results.更多还原