【摘要】 目的 :初步探讨骨桥蛋白 (Osteopontin ,OPN)与胃癌侵袭转移的关系。方法 :采用免疫组织化学SABC方法检测 12例非癌胃组织和 72例胃癌标本中OPN的表达及分布。结果 :(1) 12例非癌胃组织、30例无淋巴结转移和 2 6例有淋巴结转移及 16例有淋巴结转移且伴胃外器官转移的胃癌组织中 ,OPN的阳性表达率分别为 0、4 3 3% (13/30 )、76 92 % (2 0 /2 6 )和 87 5 % (14 /16 ) ;(2 )淋巴结转移伴有胃外器官转移和仅有淋巴结转移均与无淋巴结转移的胃癌组织中OPN的阳性表达率有明显差异 ,分别为 χ2 =8 396 ,P =0 0 0 4 ;χ2 =6 4 93,P =0 0 11。结论 :OPN与胃癌的侵袭转移密切相关 ,其分子机制需进一步研究更多还原

【Abstract】 Objective: To investigate the relationship of the osteopontin expression with the invasion and metastasis of gastric cancer. Methods: The expression of OPN was examined in 12 cases’ non-cancer gastric tissues and 72 cases’ gastric cancer tissues by using immunohistochemical method. Results: (1) The positive rates of OPN expression were 0?43.3%(13/30)?76.92%(20/26)and 87.5%(14/16) in 12 cases’ non-cancer gastric tissues,30 cases’ gastric cancer tissues without lymph nodes metastasis, 26 cases’ gastric cancer tissues with lymph nodes metastasis and 16 cases’ gastric cancer tissue with lymph nodes and other organs remote metastasis, respectively. (2) The positive rates of OPN expression in the gastric cancer tissue with lymph nodes and other organs metastasis or with lymph nodes metastasis only were entirely higher than those without lymph node metastasis, differences were respectively significent(χ 2=8.396, P=0.004; χ 2=6.493, P=0.011).Conclusions: OPN expression is closely related to the invasion and metastasis of gastric cancer , its molecular mechanism needs studying further.更多还原