【摘要】 目的:探讨油酸 (OA )所致急性肺损伤过程脑组织一氧化氮 (NO)和内皮素 (ET)的动态变化 ,了解二者在急性肺损伤时对脑的影响及其作用。方法:2 6只家兔随机分为假手术对照组和实验组 ,实验组注射 OA造成急性肺损伤模型 ,实验组以 30、6 0、90和 12 0 min为时点又分为 4个组。检测 5个组脑组织 NO和 ET含量的动态变化。 结果 :脑组织一氧化氮含量注入油酸后 30 m in组代偿性增加 ,与对照组相比差异有统计学意义 (P <0 .0 1) ,以后各时间组 NO逐渐缓慢降低 ,分别与 OA30 min组含量相比差异有统计学意义 (P<0 .0 1)。脑组织 ET含量在 OA30 m in组显著下降 ,与对照组相比差异有统计学意义 (P <0 .0 1) ,而在 6 0、90和 12 0 m in组含量又增加 ,分别与 30 min相比差异有统计学意义 (P <0 .0 5 )。结论:油酸所致急性肺损伤过程可伴发脑组织 NO和 ET水平的失衡性变化 ,NO和 ET的失衡是引起油酸所致急性肺损伤时脑功能、代谢和结构改变的主要因素之一。更多还原

【Abstract】 Objective: Dynamic changes of NO and ET in brain tissue during experimental acuteLung injury and their role were probed. Methods: The model of experimental acute lung injury was made by injecting OA in rabbit’s vein.The NO and ET of plasma and brain tissue were tested. Results: The content of NO in brain increased compensably in OA 30 min (P<0.01), but it was decreased in OA 60 min and later group (compared with OA 30 min, P<0.01). The cintent of ET in brain decreased obviously in OA 30 min group (compared with control group, P<0.01), and it was increased in OA 60 min and later group (compared with OA 30 min, P<0.05). Conchusion: Imbalance changes of NO and ET were caused by oleic acid inducd acute lung injury. It suggested that the imbalance changes were a primary agent of the function, metabolism and structure during experimental acute lung injury.更多还原