【摘要】 目的探讨氟伐他汀对糖尿病大鼠早期心肌病变的作用。方法研究对象为链脲佐菌素诱导的SD大鼠糖尿病模型,氟伐他汀(2mg·kg-1·d-1)治疗组、糖尿病对照组和正常组各10只,实验第6周末进行血糖(BG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白(a)[Lp(a)]测定及大鼠左心室前壁心肌标本的光镜HE染色和透射电镜检查。结果 治疗组与糖尿病组比较,TC、TG及Lp(a)降低,HDL-C升高(P<0.05),血糖差异无显著性(P>0.05),光镜和电镜下病理改变明显减轻。结论 氟伐他汀对糖尿病大鼠心肌细胞及微血管内皮有保护作用,提示可能对糖尿病性心肌病的治疗有重要意义。更多还原

【Abstract】 Objective To investigate the role of HMG-CoA reductase inhibitor,fluvastatin in the earlier cardiomyopathy of SD diabetic rats. Methods The level of serum total cholesterol,total triglyceride,high-density lipoprotein and Lp (a) was measured and the pathological characteristics of myocardium of left ventricle in the diabetic rats were evaluated by light microscope and electric microscope in every group. Results The group treated with fluvas-tatin for six weeks has lower serum TC,TG and Lp(a) levels, higher HDL level and lighter cardiomyopathy than the other groups. Conclusion Fluvastatin can ameliorate the lesion of myocardial cell and capillary endothelial cell in diabetic rats,which shows that fluvastatin plays a role in healing diabetic cardiomyopathy.更多还原