【摘要】 目的　探讨云南汉族人群 HL A- DQA1等位基因与高血压病的相关性。方法　应用病例 -对照相关分析方法 ,采用 PCR- SSP基因分型技术对云南汉族健康个体 91例和高血压病患者 83例 (均无血缘关系 ) ,进行 HL A- DQA1位点 10个有表达的等位基因分型 ,并进行遗传相关分析。结果　原发性高血压患者中 DQA1* 0 30 2的频率为0 .12 8,显著高于对照组 (0 .0 11) ,χ2 =19.4 0 9,P<0 .0 1,相对危险率 RR=11.4 2 ,EF为 0 .2 3。DQA1* 0 2 0 1的频率(0 .0 6 1)显著低于对照组 (0 .170 ) ,χ2 =9.876 ,P<0 .0 5。相对危险率为 0 .35。 PF为 0 .18。结论　云南汉族 HL A-DQA1等位基因与高血压病的相关性与北方汉族存在部分差异 ,HL A - DQA1* 0 30 2可能与原发性高血压易感相关 ;DQA1* 0 2 0 1可能在云南汉族原发性高血压发病中有保护作用。更多还原

【Abstract】 Objective To investigate the relationship between the alleles of human leukocyte antigens (HLA) DQA1 and essential hypertension (EH) in the Hans living in Yunnan of China. Methods 10 alleles of HLA DQA1 were typeed by polymerase chain reaction sequence-specific primers (PCR-SSP) technique in samples from 83 patients with essential hypertension, 91 healthy controls in this case-control study. All of the subjects, their grandparents and grand-grandparents are the hans living in Yunnan of China. Results The frequency of DQA1*0302 was 0.128 , significantly higher in the EH patients than in the controls(0.011). χ 2=19.409,P<0.01; Relative risk (RR) was 11.42 and etiologic factor (EF) was 0.23. The frequency of DQA1*0201 significantly decreased in the group of patients with EH in comparison to the controls ( 0.061 vs 0.170). X 2=9.876,P<0.05 .RR was 0.35 and prevent factor(PF) was 0.18. Conclusion The relationship between the alleles of HLA DQA1 and essential hypertension (EH) in the Hans living in Yunnan partly differ from that of north Chinese. HLA-DQA1*0302 related with the susceptiblity of essential hypertension in The Yunnan Hans of China.DQA1*0201 may have protection from the disease.更多还原