【摘要】 Canstatin是一种来源于Ⅳ型胶原α2链非胶原(NC1)区的血管生成和肿瘤生长抑制因子。它能剂量依赖性抑制血管内皮细胞增殖和迁移,诱导内皮细胞凋亡,在体内实验中Canstatin显著抑制实体瘤的生长。Canstatin的抗肿瘤作用可能与诱导凋亡有关,其作用机制在于抑制磷脂酰肌醇3鄄激酶/Akt(PI3鄄k/Akt)信号通路,并依赖膜死亡受体介导的信号事件。更多还原

【Abstract】 Canstatin is a novel inhibitor of angiogenesis and tumor growth, derived from the C-terminal globular non-collagenous (NC1) domain of the α2 chain of type Ⅳ collagen. It inhibits endothelial cell proliferation and migration in a dose-dependent manner, and induces endothelial cell apoptosis. In vivo experiments show that canstatin significantly inhibits solid tumor growth. The role of canstatin inhibiting tumor is related with apoptosis. Castatin-induced apoptosis is associated with phosphatidylinositol 3-kinase/Akt inhibition and is dependend upon signaling events transduced through membrane death receptor.更多还原