【摘要】 目的 :探讨幽门螺杆菌 (Helicobacterpylori,HP)感染与冠心病的关系 ,进一步了解HP感染在冠心病发病中的作用。方法 :应用14 C尿素呼气试验对冠心病组 (10 1例 )和非冠心病组 (5 3例 )进行测定 ;应用ELISA法测定血清HP抗体 (HPIgG) ,确证慢性HP感染 ;分别应用ELISA法及放射免疫法测定冠心病组IL 6及内皮素 1(ET 1)。结果 :①冠心病组血清HPIgG阳性率显著高于非冠心病组 (4 6 %vs 2 8% ,P <0 .0 5 ) ;②冠心病组14 C尿素呼气试验阳性率显著高于非冠心病组 (5 4 %vs 30 % ,P <0 .0 1) ;③冠心病组慢性HP感染者血浆ET 1水平显著高于非HP感染者 (P<0 .0 5 ) ;④现症HP感染与糖尿病及空腹血糖升高有关 (P <0 .0 5 )。结论 :HP慢性感染与冠心病有关。HP慢性感染者血浆内皮素水平显著升高。更多还原

【Abstract】 AIM: To investigate the relation of Helicobacter pylo ri (HP) infection and coronary heart disease (CHD). METHODS: HPIgG an d interleukin-6 (ELISA) were measured and Carbon-14 urea breath test was perf ormed in a total of 101 CHD cases and 53 healthy subjects, and endothelin-1 ( RIA) was measured in 53 healthy subjects. RESULTS: ① The rate of seropositive and HPIgG in CHD patients was significantly higher than that o f the controls(46% vs 28%,P<0.05). ② The positive rate for Carbon -14 urea breath test in CHD patients was significantly higher than that of the controls(54% vs 30%,P<0.01). ③ For the CHD cases ,the level of plasma endothelin-1 in these of seropositive HPIgG was higher than that of the pat ients with seronegative HP(P<0.05). ④For the cases of positive Carbon-1 4 urea breath test in CHD patients, the level of plasma GLU was higher than tha t of those with negative Carbon-14 urea breath test (P<0.05). CONC LUSION: Chronic HP infection may be associated with CHD.更多还原