【摘要】 目的　分析抗抑郁治疗对室性心律失常合并抑郁症患者的临床效果。方法　 6 3例心律失常伴抑郁症患者 ,随机分为观察组 (n =32 )和对照组 (n =31)。入组患者均给予常规抗心律失常治疗 ;观察组在抗心律失常的基础上给予心理治疗并口服百忧解 2 0mg/d ,共 12周。比较两组治疗前及 6、12周抑郁自评量表分值及心律失常情况。结果　①治疗前两组之间比较抑郁程度无显著差异 ;治疗 6周 (P =0 0 12 )及 12周(P <0 0 0 1)后 ,观察组抑郁程度显著优于对照组 ;与治疗前比较 ,对照组治疗后 6周无显著差异 ,治疗 12周有差异 (P =0 0 3) ,观察组治疗后 6周 (P <0 0 0 1)及 12周 (P <0 0 0 1)抑郁情况均显著改善 ;治疗 12周后与 6周后比较 ,对照组无差异 ,观察组抑郁情况进一步改善 (P <0 0 0 1)。②两组间心律失常发生情况对比 ,抗抑郁治疗 6周和 12周观察组均显著优于对照组 (P <0 0 0 1)。③观察组 6个月后随访结果显示心律失常的发生明显少于对照组 (P <0 0 0 1)。结论　抗抑郁治疗可明显提高室性心律失常伴抑郁患者的抗心律失常效果 ,减少复发率更多还原

【Abstract】 Objective To observe the influence of antidepressive therapy on ventricular arrhythmia patients with depression. Methods 63 ventricular arrhythmia patients were randomly assigned into following 2 groups: control group (n=31) and antidepressive group. Patients of control group were treated with conventional anti-arrhythmia therapy for 12 weeks, while patients of antidepressive group were treated with antidepressant, Fluoxetine hydrochloride (Prozac, Eli Lilly, USA) in addition to conventional anti-arrhythmia therapy for 12 weeks. Score of Self-rating depressive scale (SDS) and state of ventricular arrhythmia were evaluated at 0, 6, and 12 weeks respectively after the treatment. Results Antidepressive therapy at the basis of conventional anti-arrhythmia therapy significantly improved state of ventricular arrhythmia and reduced Score of Self-rating depressive scale (SDS). Conclusion Ventricular arrhythmia patients with depression should be treated with antidepressive therapy in addition to conventional anti-arrhythmia therapy.更多还原