【摘要】 目的　寻找具有抗癫痫作用的化合物。方法　以取代苯甲醛为起始原料经缩合、酯化、环合及酰化得目标化合物 ,对所得化合物采用最大电惊厥法测定其抗癫痫活性。结果　合成了 7个未见文献报道的 5 取代苯基 3 吡唑烷酮衍生物。结论　初步药理实验表明 ,化合物 4c、4e显示出较强的抗癫痫活性。更多还原

【Abstract】 OBJECTIVE To search compounds which have antiepileptic activity. METHOD These objective compounds were synthesized through condensation, esterification, ring closure and acylation steps using benzaldehyde as a starting material. Antiepileptic activities of these compounds were measured with the convulsive method of maximal electricity.RESULTS Seven new derivants of 5-substituted phenyl-3-pyrazo- lidinoses were synthesized. CONCLUSION The results of the pharmacological tests showed that compounds 4c,4e have appreciable antiepileptic activity.更多还原