【摘要】 目的研究功能性便秘患者直肠肛门运动功能,探讨该疾病发生的可能机制。方法测定了35例慢性功能性便秘患者和11例正常对照者的直肠肛门压力及排便功能。结果①直肠静息压、肛门括约肌静息压及其最大缩窄压等在功能性便秘患者和正常人之间无显著差异(P>0.05);②肛管高压带长度在功能性便秘患者显著高于正常人(P<0.0005);③功能性便秘患者直肠壶腹部的感觉阈值和最大耐受量显著高于正常对照组(P<0.05),直肠最大顺应性显著低于正常对照组(P<0.0005),引起直肠肛门抑制反射的直肠扩张容量在便秘组显著高于正常对照组(P<0.05),肛门松弛率在便秘组显著低于正常对照组(P<0.05);④功能性便秘患者排便时肛门内外括约肌松弛反射均障碍,尤以外括约肌明显。结论功能性便秘患者存在直肠肛门运动功能障碍,这在其发病机制中起重要作用。更多还原

【Abstract】 Objective To study the rectoanal function in patients with chronic functional constipation. Methods The rectoanal manometry was done in 35 patients with chronic functional constipation and 11 normal subjects. Results (1) The rectal resting pressure, the resting pressure and the maximum squeeze pressure of the anal sphincter were not different between the patients with chronic functional constipation and normal subjects (P> 0.05). (2) The length of high pressure zone in patients with chronic functional constipation was significantly higher than in normal subjects (P < 0.0005). (3) The rectal sensitivity, maximum tolerance and the rectal capacity causing rectoanal inhibitory reflex in patients with chronic functional constipation were significantly higher than in normal subjects (P < 0.05); The rectal compliance and anal sphincter relaxation rate were significantly lower than normal subjects (P < 0.05). (4) In chronic functional constipation, there were disorders of anal sphincter relaxation reflex, especially anal extra-sphincter. Conclusions Patients with chronic functional constipation have dysfunction of rectoanal dynamics, which play important roles in the chronic functional constipation pathogenesis.更多还原