【摘要】 目的:探讨早期干预对首发精神分裂症患者的康复效果。方法:将76例首发精神分裂症患者随机分为观察组和对照组(各38例,观察组脱落3例,对照组脱落2例)。对照组常规用氯氮平治疗,观察组在此基础上实施为期8周的心理社会干预措施,并随后进行为期1年的随访。采用阴性和阳性症状评定量表(PANSS)、住院病人护士观察量表(NOSIE-30)和复发率对康复效果进行评估。结果:随访结束时,观察组患者的PANSS总分、阳性症状及阴性症状的减分值分别为50.72±14.26,18.75±5.92,13.50±5.72,均高于对照组(41.25±13.93,15.21±6.58,9.07±6.83),差异有显著性意义(t=2.86,2.38,2.96;P<0.05～P<0.01);观察组患者的积极因素、消极因素及总评分的减分值分别为-38.58±10.14,30.47±13.26,-68.51±15.41,亦均明显高于对照组(-6.53±11.37,7.12±14.52,-11.09±22.15),差异有显著性意义(t=12.52,7.07,12.87;P<0.01);观察组1年内复发率为8.6%,明显低于对照组(30.6%),差异有显著性意义(χ2=5.42,P<0.05)。结论:对首发精神分裂症患者辅以综合性早期干预措施,可有助于改善患者的精神症状,提高患者的社会功能,并降低其复发率。更多还原

【Abstract】 AIM:To detect the rehabilitative effect of early intervention on patients with first episode schizophrene.<METHODS:Seventy six patients with first episode schizophrenia were randomly divided into observe group(n=38, 3 cases lost) and control group(n=38,2 cases lost).They were treated with clozapine and the patients of the observe group were given 8 week psychological and social intervention.Then the patients were followed up for one year and evaluated with the positive and negative symptoms scale(PANSS),nurse observation scale for inpatient evaluation 30(NOSIE 30) and the relapse rate.<RESULTS:At the end of follow up,the total PANSS score,positive symptoms score,negative symptoms score were 50.72± 14.26, 18.75± 5.92, 13.50± 5.72 respectively in the observe group,significantly higher than in the control group(41.25± 13.93, 15.21± 6.58, 9.07± 6.83)(t=2.86, 2.38, 2.96; P< 0.05- 0.01).The positive factors scores,the negative factors scores and the total score were - 38.58± 10.14, 30.47± 13.26, - 68.51± 15.41 respectively in the observe group,significantly higher than in the control group( - 6.53± 11.37, 7.12± 14.52, - 11.09± 22.15) (t=12.52, 7.07, 12.87; P< 0.01).The relapse rate of the observe group(8.6% ) was lower than that of the control group(30.6% ),and there was a significant difference(χ 2=5.42, P< 0.05).<CONCLUSION:General early intervention to first episode schizophrene can improve psychiatric symptoms and social functions and lower the relapse rate.更多还原