【摘要】 目的:探讨胶原蛋白海绵在不同类型创面上有无促进创面愈合的作用。方法:选择56例患有不同类型创面的患者,用胶原蛋白海绵敷贴于取皮区、Ⅱ度烧伤、慢性溃疡创面上或填塞于压疮所致的窦道的底部为实验组,常规治疗为对照组;观察愈合的经过、愈合的时间,并作组织病理学检查。结果:14例取皮区创面使用胶原蛋白海绵的愈合时间是(2.86±0.86)d,对照组为(4.14±0.86)d,两者比较差异有显著性意义(P<0.01);Ⅱ度烧伤创面治疗组愈合时间是(6.75±1.39)d,对照组为(10.63±1.19)d,两者比较差异有显著性意义(P<0.01);肉芽创面、慢性溃疡创面、压疮创面总显效率83.3%,总有效率100%;组织病理:对照组肉芽组织中可见较多内皮细胞增生形成的实性细胞簇及扩张的新生毛细血管,在毛细血管周围有散在新生的纤维母细胞。可见大量的胶原纤维形成,胶原纤维排列无序,部分融合。实验组早期及中期成纤维细胞及毛细血管数量明显多于对照组,成纤维细胞转化为纤维细胞的时期较对照组早,胶原纤维的产生增加,排列更有序。结论:胶原蛋白海绵对创面修复及愈合,加速肉芽组织的生长、促进慢性溃疡和压疮创面生长等方面均有显著的作用。更多还原

【Abstract】 AIM:To observe the effect of collagen sponge on various kinds of wound healing. METHODS:Fifty six patients suffering from different wounds were selected.The collagen sponge was used to compress on skin offering wounds, degreeⅡburn wounds, chronic ulcer wounds or pack in the basal part of sinus tract induced by bedsore. These were experimental groups.The control group was performed with normal treatment. The process and time of healing were observed and the examination of histological pathology was performed. RESULTS:The healing time of skin offering wounds of 14 cases by using collagen sponge was (2.86±0.86) days, and the control group was(4.14±0.86) days. There was significant difference between these two groups(P< 0.01).The healing time of degree Ⅱburn wounds was(6.75±1.39) days, the control group was (10.63±1.19) days, and there was significant difference between these two groups(P< 0.01).The effectual rate of granulation wound, chronic ulcer wounds and bedsore wounds was 83.3%, and the effective rate was 100%.Histopathology:the solid cellular clusters formed by proliferation of endothelial cell and expanded capillary vessels in the control group were observed with more newborn fibroblasts around the capillary vessels, large quantities of collagen fibers were observed with lining up disorderly and fuse partly. The quantities of fibroblasts and capillary vessels in the early and middle phase of the experimental group were more than that of control group. It was earlier when the fibroblasts transforming into myofibroblasts, more collagens were produced, and its linage is more orderly compared with control group. CONCLUSION: Collagen sponge has positive effects on the wound healing, can significantly promote the proliferation of granulation tissue, chronic ulcer and bedsore.更多还原