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有关瘢痕形成机制研究:不同皮肤成纤维细胞对羊水的反应

Mechanism of scar formulation: responses of different skin fibroblasts to amniotic fluid

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【作者】 夏扬张敏徐光刘静

【Author】 Yang Xia1, Min Zhang2,Guang Xu1, Jing Liu1,1Department of Plastic Surgery,2Central Laboratory, Beijing Railway General Hospital, Beijing 100038, China

【机构】 北京铁路总医院整形中心北京铁路总医院中心实验室北京铁路总医院整形中心 北京市100038北京市100038北京市100038

【摘要】 目的:研究正常皮肤和胎儿皮肤成纤维细胞体外培养时对羊水的不同反应,探讨瘢痕形成的机制。方法:采用成纤维细胞体外培养技术,比较正常皮肤成纤维细胞与胎儿皮肤成纤维细胞对羊水的不同反应。结果:羊水对胎儿皮肤成纤维细胞无明显影响,刺激正常皮肤的成纤维细胞。结论:体外培养的正常皮肤成纤维细与胎儿皮肤成纤维细胞生长率相同,对羊水的反应不同。

【Abstract】 AIM: To study the responses of fibroblasts in vivo of the skin from fetus and normal skin to amniotic fluid and probe into the mechanism of scar formulation. METHODS: A comparison of response to amniotic fluid was performed between the fibroblasts of the skins from fetus and from normal skin with the technique of in vitro culture. RESULTS: The growth of fibroblasts from normal skin could be stimulated by amniotic fluid, while the growth of those from fetus could not be affected. CONCLUSION: The growth rates of the fibroblasts of the skin from fetus and normal skin are same but the responses to amniotic fluid are different.

【关键词】 瘢痕成纤维细胞羊水
  • 【文献出处】 中国临床康复 ,Chinese Journal of Clinical Rehabilitation , 编辑部邮箱 ,2004年32期
  • 【分类号】R622
  • 【被引频次】3
  • 【下载频次】69
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