【摘要】 目的:观察血管性痴呆(vasculardementia,VD)患者听觉P300变化特点。方法:对30例陵川县人民医院神经内科门诊及住院的VD患者(痴呆组)和30名健康老年人(正常老人组)应用NicoletBravo脑诱发电位仪进行事件相关电位P300检测;同期应用简明精神状况量表(MMSE)评估其认知功能。结果:痴呆组MMSE(17.52±3.57)分值低于正常老年人组(26.57±1.43),差异有显著性意义(t=12.89,P<0.01);与正常老年人组相比,痴呆组点靶P300中的P2,N2,P3潜伏期长,P2,P3波幅低,非靶P2波幅低,差异均有显著性意义(t=-4.524～4.592,P<0.05～0.01);而痴呆组P300在3个脑区之间的差异无显著性意义(P>0.05);痴呆组P300中的P3波潜伏期与MMSE分值呈负相关(r=-0.534,-0.558,-0.529,P均<0.01)。结论:VD患者的P300有多指标变异;P300变异指标与其认知功能缺损的程度有关。更多还原

【Abstract】 AIM:To study the characteristics of auditory P300 in patients with vascular dementia(VD). METHODS:Event-related potential P300 was detected with the Nicolet Bravo instrument in 30 VD patients(VD group) in the Outpatient Department of Neurology and hospitalized in the People’s Hospital of Lingchuan County and 30 healthy elderly people(normal control group),and their cognitive function was assessed with the mini-mental state examination(MMSE). RESULTS:The score of MMSE in the VD group(17.52±3.57) was significantly lower than that in the normal control group(26.57±1.43)(t=12.89,P< 0.01).The latencies of P3,N2 and P3 in the P300 target were longer,the amplitudes of P2 and P3 were lower and that of non-target P2 was lower in the VD group,which were significantly different from those in the normal control group(t=-4.524 to 4.592,P< 0.05 to 0.01);there were insignificant differences in the P300 among the 3 brain areas of the VD group(P >0.05). The latency of P3 in P300 was negatively correlated with the score of MMSE in the VD group(r=-0.534,-0.558,-0.529,P< 0.01). CONCLUSION:Many P300 indexes are variant in VD patients and correlated with the cognitive impairment severity.更多还原