【摘要】 目的:研究心理行为干预对药物治疗动脉粥样硬化(arteriosclerosis,AS)效果的影响。方法:选择在郑州铁路中心医院内科门诊,根据患者病史、查体以及血脂、心电图、脑血流图、头颅CT等检查确诊为动脉粥样硬化的患者64例,除外其他精神病及严重心理障碍患者。随机将64例患者分为干预组与对照组,两组均用洛伐他汀进行治疗,干预组在洛伐他汀药物治疗基础上配合心理疗法;以艾森克人格问卷(EPQ)、症状自评量表(SCL-90)、特质性应对项目作为评估工具,在治疗前、治疗后12周分别进行问卷调查及血液生化指标的检测。结果:治疗前两组心理量表测试及血液生化指标检测结果差异无显著性意义(P>0.05);治疗后干预组心理测试结果及血液生化指标改善明显优于对照组(P<0.05)。干预组治疗后高密度脂蛋白胆固醇水平犤(1.14±0.32)mmol/L犦明显较治疗前犤(1.03±0.20)mmol/L犦升高,与对照组治疗后犤(1.10±0.24)mmol/L犦比较,差异也有显著性意义(P<0.05～0.01)。结论:心理行为干预对洛伐他汀临床疗效的发挥具有积极的协同作用。更多还原

【Abstract】 AIM:To observe the influence of mental behavior intervention in treating arteriosclerosis(AS) with lovastatin. METHODS:A total of 64 patients,who had been diagnosed to have AS according to disease history,examination and by electrocardiograph, rheoencephalogram and skull CT etc.were selected.Patients with certain mental diseases and serious psychologic obstacles were excluded.The 64 patients were randomly divided into intervention group and control group,receiving lovastatin.In the intervention group,psychotherapy was accompanied with lovastatin; Eysenck personality inventory(EPQ), symptom checklist 90(SCL 90) and characteristic coping program were used as tools of evaluation.The questionnaire investigation and vascular biochemistry marker were measured before and 12 weeks after treatment respectively. RESULTS:Differences from the results of mental scale test and vascular biochemistry marker in the two groups before the treatment had no significant meaning(P >0.05);however, after the treatment,results of mental scale test and vascular biochemistry marker in the intervention group were significantly better than those in the control group(P< 0.05).In the intervention group,high density lipoprotein cholesterol(HDL C) level[(1.14±0.32) mmol/L]was increased as compared with that before treatment [(1.03±0.20) mmol/L];and indicated significant difference as compared with that of the control group after the treatment[(1.10±0.24) mmol/L] (P< 0.05 to 0.01). CONCLUSION:The intervention of psychological behavior has positively cooperative effect on the clinical treatment with lovastatin更多还原