【摘要】 目的:研究小脑传入神经纤维对成年大鼠中枢耳石器神经元生理特性的影响。方法:用外科吸引术毁损小脑蚓垂和小结,观察中枢耳石器神经元自发性放电活动的变化。结果:小脑蚓垂小结毁损后,规则型放电神经元的比例增加,C神经元呈现出规则的和不规则的两种放电类型,而少数I神经元表现出规则型放电。同时,各类神经元的自发性放电均值或增强或减弱,与正常对照组相比,其间的差异均具有显著性意义。结论:小脑蚓垂小结毁损后,中枢耳石器神经元的自发性放电活动受到了明显影响。提示当动物处于正常生理状态下,具有功能特性的中枢耳石器神经元的自发性放电活动受小脑蚓垂和小结的调控。更多还原

【Abstract】 AIM:To investigate the contribution of cerebellar inputs to the spontaneous discharge properties of central otolith neurons in adult rats. METHODS:Uvulonodular lobe of cerebellum was lesioned by surgical aspiration to observe the changes of spontaneous discharge activity of central otolith neurons. RESULTS:After uvulonodular lesion, the ratio of regular discharge neurons increased,C neurons exhibited both regular and irregular discharge pattern while a few I neurons showed regular discharge patterns.Meanwhile, the mean spontaneous discharge rates of all kinds of neurons were increased or decreased and the differences were significant as compared with those of control groups(t=2.154 9-5.044 4,P< 0.05-0.001). CONCLUSION:The spontaneous discharge activities of central otolith neurons were affected significantly after uvulonodular lesion.These findings suggest that under normal physiology condition,the spontaneous discharge activities of central otolith neurons which have functional characteristics are regulated by the uvulonodular cerebellum.更多还原