【摘要】 目的:研究静脉应用大剂量白蛋白对重症新生儿缺氧缺血性脑病(hypoxicischemicencephalopathy,HIE)的疗效。方法:选择重症HIE患儿76例,分为2组:大剂量白蛋白治疗组48例,静脉滴注人血白蛋白2g/(kg·d),连续3～5d;常规治疗(对照)组28例,给予常规治疗。在日龄7,14,25～30d连续检查3次新生儿神经行为(neonatalbehavioralneurologicalassessment,NBNA)评分;3,6个月时用《儿心0～4岁精神发育量表》测定发育商。结果:大剂量白蛋白可显著性提高重度HIE新生儿NBNA评分(白蛋白组:25.33±3.19～35.91±3.08;常规组:26.01±3.47～32.11±3.20),差异有显著性意义(t=2.90～2.98,P<0.01);亦升高3,6个月时发育商(白蛋白组:94.01±10.81,93.10±9.07;常规组:80.01±12.33,84.91±10.19),差异有显著性意义(t=2.49,1.84,P<0.01)。结论:静脉滴注大剂量人血白蛋白可明显改善重度HIE新生儿的神经行为与及发育商。更多还原

【Abstract】 AIM:To study the effect of venous drip of large dose of human albumin in neonates with severe hypoxic ischemic encephalopathy(HIE) METHODS:Seventy six severe HIE infants were divided into two groups:albuman treated group (n=48),receiving venous drip of 2 g/kg per day human albumin for 3-5 days successively,and control group(n=28),receiving routine treatment.The neonatal behavioral neurological assessment(NBNA) score was evaluated for 3 times continuously on day 7,14 and on days 25-30,respectively.Furthermore,the development quotient was assessed by 0-4 years old children psychological and mental development scale at 3,6 months. RESULTS:Large dose of human albumin could improve the NBNA scores (25.33±3.19 -35.91±3.08),significantly different from those in the control group(26.01±3.47 -32.11±3.20)(t=2.90-2.98,P< 0.01),The development quotient was also improved in the albuman treated group(94.01±10.81,93.10±9.07)at 3 and 6months,significantly different from that in the control group(80.01±12.33,84.91±10.19)(t=2.49,1.84,P< 0.01). CONCLUSION:Venous drip of large dose of human albumin can obviously improve the neuroethology and development quotient in neonates with severe HIE.更多还原