【摘要】 目的:观察抑郁情绪对稳定型心绞痛患者心肌缺血频度和程度的影响,寻找其规律性。方法:93例稳定型心绞痛患者接受了汉密顿抑郁量表(HAMD)调查和24h动态心电图检查。结果:93例稳定型心绞痛患者中有抑郁情绪患者(HAMD≥8分)50例(53.8%),其中轻度抑郁21例(22.6%),中度抑郁18例(19.4%),重度抑郁11例(11.8%)。64例无或轻度抑郁患者心肌缺血频度为(6.51±2.37)次/d,心肌缺血程度为(1.25±0.40)mm/次,明显低于度患者犤n=29,(10.89±3.24)次/d和(1.62±0.54)mm/次犦(t=3.296和2.974,P均<0.01)。按缺血频度分组比较中,频度多组(≥8次/d,n=47)的焦虑躯体化、昼夜变化、迟缓、睡眠障碍等HAMD分项评分明显高于频度少组(<8次/d,46例)(t=2.042～2.976,P<0.01～0.05)。按缺血程度分组比较中,程度重组(≥1.5mm/次,42例)的焦虑躯体化、昼夜变化、睡眠障碍和绝望感等HAMD分项评分明显高于程度轻组(<1.5mm/次,51例)(t=2.252～2.962,P<0.01～0.05)。结论:稳定型心绞痛患者的抑郁情绪与其心肌缺血发作频度和程度密切相关,寻找有效和适当的干预方法非常必要。更多还原

【Abstract】 AIM:To observe the effects of depression on the myocardial ischemic frequency and degree in patients with stable angina pectoris(SAP),and to explore the regularity. METHODS:Totally 93 patients with SAP were inquired by Hamilton depression rating scale for depression(HAMD) and monitored by dynamic electrocardicgram for 24 hours. RESULTS:Of the 93 SAP patients,depressive symptom (HAMD≥8)was found in 50 cases(53.8%),including 21 cases(22.6%) of mild depression,18 cases(19.4%) of moderate depression and 11 cases(11.8%) of severe depression.The ischemic frequency(IF) and degree(ID) in the patients with mild depression or without depression(64 cases) were(6.51±2.37)times per day and(1.25±0.40)mm per time,obviously lower than those in the patients with moderate or severe scale(29 cases,[10.89±3.42]times per day and[1.62±0.54]mm per time)(t=3.296, 2.974,P< 0.01).The elevated HAMD scales of anxious somatization,changes of day and night,retardation and sleep disorder in the large IF group(≥8 times per day,47 cases) were obviously different from those in the small IF group(< 8 times per day,46 cases)(t=2.042-2.976,P< 0.01-0.05).The elevated HAMD scales of anxious somatization,diurnal variation,sleep disorder,feeling of despair in the evere group(≥1.5 mm per time,42 cases) were significantly higher than those in the mild group(< 1.5 mm per time,51 cases)(t=2.252-2.962,P< 0.01-0.05). COUCLUSION:Depression is closely related to the frequency and degree of myocardial ischemia in patients with SAP,so it is very necessary to find effective and proper interventions.更多还原