【摘要】 目的:探讨加兰他敏对血管性痴呆(vasculardementia,VD)记忆和生活质量的临床疗效。方法:将60例符合VD诊断标准的患者分为治疗组和对照组,各30例,对照组用脑活素治疗,治疗组在对照组基础上加用氢溴酸加兰他敏3个疗程。两组患者治疗前及6个月后韦氏记忆量表(WMS)、长谷川痴呆量表(HDS)、日常生活能力量表(ADL)得分作为疗效评定。结果:治疗组患者治疗后WMS(44.36±14.44)分,HDS(17.73±7.52)分,ADL(24.67±8.29)分明显优于对照组(34.27±7.04),(13.46±7.02),(30.57±7.63)分(t=2.16～3.35,P<0.01),与治疗前积分差异亦有显著性意义(P<0.01)。结论:加兰他敏治疗VD是有效、安全的,具有临床实用价值。更多还原

【Abstract】 AIM:To explore the clinical effect of galanthamine on memory and quality of li fe(QOL) in patients with vascular dementia(VD). METHODS:Sixty VD patients were randomized into control and treatment groups of 30 in each group.Cerebrolysin was administrated in the control group,and in add ition,galantamin hydrobromide was used in the treatment group for 3 courses.Wech sler Memory Scale(WMS),Hasegawa’s Dementia Scale(HDS),and activities of daily li ving scale(ADL) were applied in the two groups before and 6 months after treatme nt. RESULTS:The scores of WMS,HDS and ADL were 44.36±14.44, 17.73±7.52 and 24.67 ±8.29 respectively in the treatment group, superior to those in the control gro up(34.27±7.04,13.46±7.02 and 30.57±7.63 respectively)(t=2.16-3.35,P< 0.01).T here were significant differences before and after treatment(P< 0.01). CONCLUSION:Galanthamine is safe and effective for the treatment of VD in clini c.更多还原