【摘要】 目的:观察原发性高血压患者血清Ⅰ型前胶原羧基端肽(typeⅠprocolla-gencarboxyterminalpropeptide,PⅠCP)、Ⅲ型前胶原N端肽(typeⅢpro-collagenaminoterminalpropeptide,PⅢNP)、胰岛素样生长因子-I(insulin-likegrowthfactor-I,IGF-I)及转化生长因子-β1(transforminggrowthfactor-β1,TGF-β1)水平的改变,探讨它们在高血压左心室肥厚(leftventricularhypertrophy,LVH)发生发展中的机制。方法:采用放射免疫法测定36例原发性高血压患者(LVH20例,非左心室肥厚(non-leftventricularhypertrophy,NLVH)16例及25例正常对照者血清PⅠCP,PⅢNP,IGF-I和TGF-β1,并对结果进行对比分析。结果:原发性高血压组血清PⅠCP、PⅢNP、IGF-I和TGF-β1的水平(μg/L)分别为162.8±32.7,7.6±3.4,129.5±38.2和40.3±5.4,对照组分别为95.3±13.8,3.8±1.3,68.7±12.5和24.8±4.9,两组比较差异均有显著性意义(t=9.718,5.314,7.661,11.44,P均<0.001),其中LVH组各指标的水平(198.6±35.5,8.9±4.6,143.7±35.8,44.2±6.2)较NLVH组明显升高差异有显著性意义(t=2.474～6.947,P<0.001～0.05)。结论:原发性高血压患者可能有Ⅰ型胶原及Ⅲ型胶原的合成增加、降解相对不足,测定上述各指标在高血压LVH中具有重要的作用。更多还原

【Abstract】 AIM:To observe the changes of levels of typeⅠprocollagen carboxyterminal prop eptide(PⅠCP),type Ⅲprocollagen aminoterminal propeptide(PⅢNP),insulin-like g rowth factor-Ⅰ(IGF-Ⅰ) and transforming growth factor-β1(TGF-β1) in patie nts with essential hypertension,and to explore the mechanism of the above parame ters in the occurrence and development of left ventricular hypertrophy (LVH). METHODS:Serum levels of PⅠCP,PⅢNP,IGF-I and TGF-β1 were measured by radio immunoassay in 36 patients with essential hypertension(20 cases of LVH and 16 ca ses of non-LVH) and 25 healthy controls,and comparative analysis was conducted to the results. RESULTS:In the essential hypertension group,the serum levels of PⅠCP,PⅢNP,IG F-I and TGF-β1 were(162.8±32.7),(7.6±3.4),(129.5±38.2) and(40.3±5.4) μg/ L,respectively,significantly different from those in the control group[(95.3±13 .8),(3.8±1.3),(68.7±12.5) and(24.8±4.9) μg/L](t=9.718,5.314,7.661,11.44,all P< 0.001);and the above parameters in the LVH group were obviously increased com pared with the NLVH group(t=2.474-6.947,P< 0.001-0.05). CONCLUSION:PⅠCP and PⅢNP may be the sensitive serum markers of myocardial co llagen synthesis.Myocardial fibrosis may be due to the excessive synthesis and i nsufficient degradation of collagen,and the measurement of the above parameters plays an important role in LVH of essential hypertension.更多还原