【摘要】 目的:研究pH敏感性壳聚糖海藻酸钠水凝胶体系的溶胀特性及在药物缓释中的应用。方法:在温和条件下制备壳聚糖-海藻酸钠复合水凝胶颗粒,研究其在胃的pH环境(pH=1.4)和肠道pH环境(pH=7.4)的溶胀动力学并考察各种因素对凝胶溶胀性能的影响,利用该凝胶的特性制备酮洛芬微囊,测定其在人工胃液和人工肠液中的缓释效果。结果:该凝胶颗粒在pH=1.4的盐酸缓冲溶液中溶胀度较小,而在pH=7.4的磷酸盐缓冲溶液中溶胀度很大,用它制备的酮洛芬微囊具有明显的缓释效果。结论:讨论了壳聚糖浓度,海藻酸钠浓度,钙离子浓度对凝胶溶胀性能的显著影响以及利用这些特性制备的酮洛芬微囊的缓释效果。更多还原

【Abstract】 AIM:To study the swelling characteristic of compound sodium alginate-chitosan gel and its application in slow releasing of drugs.METHODS:The granules of compound sodium alginate-chitosan gel were made under mild conditions for studying its swelling kinetics in the pH 1.4 environment of stomach and pH 7.4 of environment of small intestine and the effects of various factors on its swelling characteristic.Ketoprofen microcapsule was made accordi ng to the gel’s characteristic for detecting its slow releasing effect in the ar tificial gastric and intestinal fluids.RESULTS:Degree of swelling of the gel was lower in hydrochloric acid buffer of pH 1.4 and was much higher in hydrochloric acid buffer of pH 7.4. Ketoprofen mi crocapsules made of this kind of gel had significantly slow releasing effect of drugs.CONCLUSION:The effects of the contents of chitosan, sodium alginate and calciu m ion content on the swelling characteristics of the gel was discussed and how t o made ketoprofen microcapsules of ideal releasing effect according to the chara cteristics.更多还原