【摘要】 目的:研究中年大鼠主动脉血管形态结构的变化及抗动脉粥样硬化的作用。方法:40只雄性SD大鼠随机分为4组:对照组、服药组、运动组和运动+服药组,每组10只。后二组进行游泳训练8周(5d/周,1.5h/d)。结果:①光镜观察:对照组大鼠主动脉管壁增厚,管腔狭窄,并有轻度血管内皮细胞完整性破坏现象;服药组和运动组管壁增厚和管腔狭窄现象明显抑制;服药+运动组血管壁菲薄,管腔较大,血管内皮细胞完整无管壁增厚和管腔狭窄。⑵主动脉血管图像分析:与对照组相比,服药组、运动组和运动+服药组大鼠血管动脉外径和血管总面积分别增加15.0%,10.1%,19.9%和32.8%,29.0%,38.8%,差异有显著性意义(t=2.3,1.4,3.1,9.9,8.3,12.9,P<0.05);血管管壁厚度则分别减少31.3%,24.9%,33.2%,差异有显著性意义(t=1.6,1.3,1.7,P<0.05)。结论:中药紫丹蓝和运动训练在维持血管壁内皮细胞完整性、增强血管壁舒张功能及抗动脉粥样硬化方面具有显著作用。更多还原

【Abstract】 AIM:To study the morphological changes of aorta blood vessel and effect of antiatherosclerosis in middle aged rats. METHODS:Forty male SD rats were randomly divided into four groups of 10 rats each:control group,drug group,exercise group and drug+ exercise group.The exercise and drug+ exercise group conducted swimming exercise training program for 8 w(5 d/w,1.5 h/d ). RESULTS:① Observation through light microscope:there were some thickness and stenosis in aorta,light complete damage of endothelial cells in the control group;thickness and stenosis in the drug and exercise groups were significantly prohibited;the vessel wall and lumen were thin and large in the drug+ exercise group,the endothelial cells were intact without thickness and stenosis.② Image pattern analysis:Compared with the control group,the diameter increased by15.0% ,10.1% and 19.9% ,the total area increased by 32.8% ,29.0% and 38.8% ,respectively in the drug,exercise and drug+ exercise groups,the differences were significant( t=2.3,1.4,3.1,9.9,8.3,12.9,P< 0.05) ,while the thickness was decreased by 31.3% , 24.9% and 33.2% ,the differences were significant( t=1.6,1.3,1.7,P< 0.05). CONCLUSION:Zidanlan and exercise training have a significant effect in keeping the integrity of vessel wall and improving its relax function.That may be beneficial to antiatherosclerosis.更多还原