【摘要】 目的:利用功能磁共振成像技术(fMRI),研究大脑皮质运动系统运动准备和执行活动的空间分布。方法:采用组块设计,分别对受试者执行实际运动和想象运动时的脑活动进行fMRI扫描,并运用多重回归分析和一般线性检验相结合的方法对运动准备和执行成分的空间分布进行分析。结果:大脑皮质运动系统各运动相关区均不是单一功能区,而是同时参与运动准备和执行两种成分;这两种成分各脑区的分布也不是均一的或者杂乱无章的,而是呈特征性梯度分布:其中辅助运动区(SMA)和运动前区(PMC)自前至后、后顶叶皮质(PPC)自后至前,其参与运动准备的程度越来越低,参与运动执行的程度越来越高。结论:组成大脑皮质运动系统的各随意运动脑区都不是孤立的功能单元,而是一个个同时包含运动执行和准备成分、并具有一定层次的功能子系统;大脑皮质运动系统实际上就是由这些功能上紧密相连的并行加工的子系统组成。更多还原

【Abstract】 AIM: To study the spatial distribution of preparation-and execution-rela ted activity in cerebral cortical locomotor system by functional magnetic resona nce imaging (fMRI). METHODS:fMRI was performed in all the subjects to detect brain activity by me ans of blocking methods during actual activity and imaginary activity.Multiple r egression analysis and general linear examination were used for the analysis of the distribution of preparation-and execution-related activity. RESULTS:Motor-related cortical areas functioned as preparation and executio n simultaneously.The distribution of preparation and execution presented charact eristics and gradient.Supplementary motor area(SMA)and premotor cortex(PMC)had a declined tendency to participate in preparation activity,but an increased tende ncy to participate in execution activity from the front to the back;while poster ior parietal cortex(PPC)was from the back to the front. CONCLUSION:Motor-related cortical areas all include preparation and executi on,possessing a certain functional subsystem.Actually,brain cortical motor syste m consists of subsystems mentioned above,which is closely related with each othe r in function.更多还原