【摘要】 SM22α是一种分化型血管平滑肌细胞(VSMC)的标志基因,编码一种22 kDa的收缩调节蛋白。由于SM22α基因结构短小,表达具有VSMC特异性、调控机制较为清楚,因而被广泛用于VSMC发育分化的研究。利用该基因的表达调控特征,设计可在VSMC中高表达目的蛋白的人工启动子,是心血管病基因治疗的新策略。更多还原

【Abstract】 SM22α is one of vascular smooth muscle cell (VSMC) marker genes, and encodes a 22 kDacontraction-associated protein. SM22α gene is characterized by simple structure and restricted expression indifferentiated VSMC. Thus, it has widely been used to study the regulatory mechanisms of VSMC-specific geneexpression. On the basis of the features of its expression, recombinant promoters containing SM22α regulatoryregion have been developed, and serve as a tool for gene therapy to trigger the target protein expression in VSMC.更多还原