【摘要】 目的 :观察扶正抑瘤颗粒对放疗食管癌患者癌组织中CD4 4v6、nm2 3 H1表达的影响。方法 :6 3例患者随机分为扶正抑瘤颗粒加放疗组 (治疗组 ,30例 )和常规放疗组 (对照组 ,33例 )。于治疗前和治疗 2 1d后做电子胃镜检查 ,活检瘤组织 ,固定、脱水、浸蜡包埋、切片 ,用免疫组化SABC法检测CD4 4v6、nm2 3 H1。结果 :治疗 2 1d后 ,治疗组与对照组CD4 4v6分别为4 0 .0 0 %、6 9.70 % ,两组比较有显著性差异 (P <0 .0 5 ) ;而治疗组和对照组的nm2 3 H1分别为 2 0 .0 0 %、2 1.2 1% ,两组比较无显著差异 (P >0 .0 5 )。结论 :扶正抑瘤颗粒可降低放疗食管癌组织中CD4 4v6表达 ,从而起到抑制食管癌浸润和转移的作用更多还原

【Abstract】 Objective:To evaluate the effects of Fuzheng Yiliu Granule on the expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy.Methods:Sixty-three cases of esophageal carcinoma were randomly divided into two groups:Fuzheng Yiliu Granule plus radiotherapy treated group (n=30) and radiotherapy treated group (n=33). The carcinoma specimens were obtained through endoscopic biopsy before and after twenty-one days of treatment. The expression of CD44v6 and nm23-H1 was determined in the sixty-three specimens of esophageal carcinoma by immunohistochemical SABC methods. Results:After twenty-one days of treatment, the positive rates of CD44v6 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 40.0% and 69.7%, respectively, and there was significant difference between the two groups (P<0.05). The positive rates of nm23-H1 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 20.0% and 21.2%, respectively, and the difference was not significant between the two groups (P>0.05).Conclusion:Fuzheng Yiliu Granule can lower the expression of CD44v6 in esophageal carcinoma, and may prevent infiltration and lymph node metastasis of esophageal carcinoma.更多还原